Meta-analysis of volumetric abnormalities in cortico-striatal-pallidal- thalamic circuits in major depressive disorder

Abstract

Background Abnormalities in cortico-striatal-pallidal-thalamic (CSPT) circuits have been implicated in major depressive disorder (MDD). However, the robustness of these findings across studies is unclear, as is the extent to which they are influenced by demographic, clinical and pharmacological factors.Method With the aim of clarifying these questions, we conducted a meta-analysis to map the volumetric abnormalities that were most robustly identified in CSPT circuits of individuals with MDD. A systematic search identified 41 studies meeting our inclusion criteria. Results There were significant volume reductions in prefrontal (especially orbitofrontal) and anterior cingulate cortices, and al..